Chromatin potentiates transcription
نویسندگان
چکیده
منابع مشابه
The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates.
Weak hypomorph mutations in the enhancer of yellow genes, e(y)1 and e(y)2, of Drosophila melanogaster were discovered during the search for genes involved in the organization of interaction between enhancers and promoters. Previously, the e(y)1 gene was cloned and found to encode TAF(II)40 protein. Here we cloned the e(y)2 gene and demonstrated that it encoded a new ubiquitous evolutionarily co...
متن کاملDNA microarrays, chromatin, transcription
The DNA microarray-based technique has been developed to semi-quantitatively measure the in vivo global chromatin condensation state at the resolution of a gene. Chromatin was fractionated due to the differential solubility of histone H1-containing and histone H1-free nucleosomes. A set of genes non-randomly distributed between histone H1-free (uncondensed or open) and histone H1-containing (co...
متن کاملTranscription factor access to chromatin.
The question of how sequence-specific transcription factors access their cognate sites in nucleosomally organized DNA is discussed on the basis of genomic footprinting data and chromatin reconstitution experiments. A classification of factors into two categories is proposed: (i) initiator factors which are able to bind their target sequences within regular nucleosomes and initiate events leadin...
متن کاملTranscription Elongation: TLKing to Chromatin?
Tousled-like kinases (TLKs) have important functions during the cell cycle in eukaryotes. The TLK family was named after its founding member, the product of the TOUSLED gene which is essential for normal development of the plant Arabidopsis thaliana [1]. More recently, these kinases have been implicated in deposition of chromatin following DNA replication. During S phase, nucleosomes must be as...
متن کاملChromatin transcription: Clearing the gridlock
A factor has been purified that specifically facilitates RNA chain elongation in a chromatin context; the properties of this factor help to define the challenges that lie ahead in understanding how RNA polymerase manages to transcribe DNA that is packaged into chromatin.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1620312114